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Letters |1 July 1998

Reversible Dysgeusia Attributed to Losartan

Marten Heeringa, MSc; Eugene P. van Puijenbroek, MD

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Author, Article, and Disclosure Information
  • Netherlands Pharmacovigilance Foundation LAREB; Hertogenbosch, the Netherlands
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TO THE EDITOR:
Like angiotensin-converting enzyme (ACE) inhibitors, losartan interferes with the renin-angiotensin-aldosterone system by decreasing angiotensin II-mediated effects. Although losartan and ACE inhibitors have similar therapeutic potency, losartan reportedly has fewer adverse effects because of selective antagonism of angiotensin I receptors [1]. Schlienger and colleagues [2] recently described a patient in whom losartan induced reversible ageusia; we present two similar reports.
A 49-year-old woman had been using enalapril (10 mg/d) for the treatment of hypertension. Because of fatigue, therapy was changed to losartan (50 mg/d). One week after the initiation of therapy, the patient reported a persistent metallic taste, a tickling cough, and intestinal symptoms. After discontinuation of losartan therapy, symptoms disappeared. Concomitant medications were carbaspirin calcium (38 mg/d), cetirizine (10 mg/d), and ranitidine (150 mg three times daily).
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Heeringa M, van Puijenbroek EP. Reversible Dysgeusia Attributed to Losartan. Ann Intern Med. ;129:72. doi: 10.7326/0003-4819-129-1-199807010-00023

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Published: Ann Intern Med. 1998;129(1):72.

DOI: 10.7326/0003-4819-129-1-199807010-00023

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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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