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Letters |1 December 1998

Pharmacokinetic Interaction between Saquinavir and Cyclosporine

Kees Brinkman, MD, PhD; Frans Huysmans, MD, PhD; David M. Burger, PharmD, PhD

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Copyright ©2004 by the American College of Physicians
  • University Hospital Nijmegen; Nijmegen, the Netherlands
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An HIV-positive kidney transplant recipient who was receiving cyclosporine and prednisone started zidovudine and lamivudine therapy shortly after kidney function had stabilized. When protease inhibitors became available, saquinavir was added; levels of both drugs were monitored.
Without saquinavir, the cyclosporine trough levels in this patient were stable at a dosage of 150 mg twice daily (150 to 200 µg/L). Within 3 days after saquinavir therapy began at a dosage of 1200 mg three times daily, the patient reported fatigue, headache, and gastrointestinal discomfort and the trough level of cyclosporine tripled to 580 µg/L. After cyclosporine and saquinavir...
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Brinkman K, Huysmans F, Burger DM. Pharmacokinetic Interaction between Saquinavir and Cyclosporine. Ann Intern Med. 1998;129:914–915. doi: 10.7326/0003-4819-129-11_Part_1-199812010-00022

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Published: Ann Intern Med. 1998;129(11_Part_1):914-915.

DOI: 10.7326/0003-4819-129-11_Part_1-199812010-00022

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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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