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Letters |2 March 1999

Effects of Hypertriglyceridemia on Platelet Counts in Automated Hematologic Analysis

Osamu Kabutomori, BSc; Yoshinori Iwatani, MD; Miwako Kabutomori, BSc

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Author, Article, and Disclosure Information
  • Osaka University Hospital; Osaka 565-0871, Japan (Kabutomori) Osaka University; Osaka 565-0871, Japan (Iwatani) Kawarazaki Hospital; Osaka 567-0036, Japan (Kabutomori)
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TO THE EDITOR:
Levels of chylomicron are increased in the sera of patients with hypertriglyceridemia. Chylomicrons, which contain triglyceride in high concentrations, are usually 0.5 to 1.0 µm in diameter (1). Sometimes, however, they reach a diameter of 1.5 to 3.5 µm, which is equal to the size of a platelet in peripheral blood (2). Therefore, we examined the effect of hypertriglyceridemia on platelet counts measured with two types of automated hematologic analyzers: the NE-8000 (Sysmex, Kobe, Japan), which uses the electrical impedance method, and the THMS-H2 (Bayer, West Haven, Connecticut), which uses the optical method (3).
Platelet counts were 0 when samples of normal sera were analyzed with the automated hematologic analyzers (Table on page 452). However, pseudoplatelets were detected when samples of hypertriglyceridemic sera whose triglyceride concentrations were more than 11.29 mmol/L were measured with both automated hematologic analyzers. The pseudoplatelet counts were higher in the analyzer that used the optical method (THMS-H2) than in the one that used the impedance method (NE-8000). Furthermore, when we mixed blood treated with EDTA-2K from a normal patient with normal serum treated with EDTA-2K or hypertriglyceridemic serum, the platelet counts measured with both automated analyzers were higher in hypertriglyceridemic sera than in normal sera. Furthermore, when blood was mixed with hypertriglyceridemic serum, the platelet counts were higher in the NE-8000 analyzer than in the THMS-H2 analyzer.
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Kabutomori O, Iwatani Y, Kabutomori M. Effects of Hypertriglyceridemia on Platelet Counts in Automated Hematologic Analysis. Ann Intern Med. 1999;130:452. doi: 10.7326/0003-4819-130-5-199903020-00011

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Published: Ann Intern Med. 1999;130(5):452.

DOI: 10.7326/0003-4819-130-5-199903020-00011

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