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Letters |16 March 1999

Primaquine Prophylaxis against Malaria

Jaime Soto, MD; Jonathan Berman, MD, PhD

Article, Author, and Disclosure Information
Author, Article, and Disclosure Information
  • Universidad Militar Nueva Granada; Bogota, Colombia (Soto) Walter Reed Army Institute of Research; Washington, DC 20307 (Berman)
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IN RESPONSE:
The comments of Heppner and colleagues and Dr. Barry are useful and contribute to a dialogue on the important subject of malaria prophylaxis.
We appreciate Heppner and colleagues' emphasis on points that we also emphasized: the risk of giving primaquine to G6PD-deficient persons and the higher efficacy of the drug for P. falciparum than for P. vivax. We also appreciate the comments on the question of mefloquine in pregnancy. When we stated that “the risk of mefloquine prophylaxis … has not been clinically evaluated,” we might have added the word “thoroughly” before “clinically evaluated.” The risk has been and is being examined, and reasonable persons can disagree on the drug's safety in pregnancy (1, 2). We chose not to take sides and simply implied that final evaluation remains.
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Soto J, Berman J. Primaquine Prophylaxis against Malaria. Ann Intern Med. 1999;130:536–537. doi: 10.7326/0003-4819-130-6-199903160-00020

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Published: Ann Intern Med. 1999;130(6):536-537.

DOI: 10.7326/0003-4819-130-6-199903160-00020

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