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Letters |7 September 1999

Vulnerable Plaque

Guha Krishnaswamy, MD; David S. Chi, PhD; Jim Kelley, PhD

Article, Author, and Disclosure Information
Author, Article, and Disclosure Information
  • James H. Quillen College of Medicine; East Tennessee State University; Johnson City, TN 37614 (Krishnaswamy)
    James H. Quillen College of Medicine; East Tennessee State University; Johnson City, TN 37614 (Chi)
    James H. Quillen College of Medicine; East Tennessee State University; Johnson City, TN 37614 (Kelley)
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TO THE EDITOR:
Kullo and colleagues have presented an excellent review of the cellular and molecular aspects of a vulnerable plaque (1). Their Table 1 mentions the cellular composition of rupture-prone plaques and lists macrophages, T cells, and mast cells. However, although their discussion involves the role of macrophages, T cells, and smooth-muscle cells, little attention was paid to the potential role of mast cells in plaque instability or rupture.
Kaartinen and colleagues (2) demonstrated very clearly that mast cells localize to areas of erosion or rupture sites of atheromas, and these cells expressed tumor necrosis factor-α. Mast cells...
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Krishnaswamy G, Chi DS, Kelley J. Vulnerable Plaque. Ann Intern Med. 1999;131:392–393. doi: 10.7326/0003-4819-131-5-199909070-00015

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Published: Ann Intern Med. 1999;131(5):392-393.

DOI: 10.7326/0003-4819-131-5-199909070-00015

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1999 American College of Physicians
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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