Skip Navigation
Menu
Letters |21 September 1999

Hemochromatosis and Vitamin C

James C. Barton, MD; Paul C. Adams, MD; Lawrie W. Powell, MD, PhD

Article, Author, and Disclosure Information
Author, Article, and Disclosure Information
  • Southern Iron Disorders Center; Birmingham, AL 35209 (Barton)
    London Health Sciences Center; London, Ontario N6A 5A5, Canada (Adams)
    Queensland Institute of Medical Research, University of Queensland; Brisbane 4029 QLD, Australia (Powell)
×
FULL TEXT
IN RESPONSE
In persons who have thalassemia major with iron overload, vitamin C (ascorbic acid) can mobilize iron stored in reticuloendothelial cells, sometimes leading to acute cardiac toxicity (1). Withdrawal of vitamin C supplementation has been associated with improvement of left ventricular function, and vitamin C deficiency may protect against the cardiac effects of iron overload in patients with thalassemia major (1). In contrast, there is little published evidence that vitamin C mobilizes large quantities of iron or induces acute (or chronic) toxicity in hemochromatosis. Urinary iron excretion, a measure of iron mobilization, was not increased by oral...
FULL TEXT
PDF
Not Available
Citations
Citation

Barton JC, Adams PC, Powell LW. Hemochromatosis and Vitamin C. Ann Intern Med. 1999;131:476. doi: https://doi.org/10.7326/0003-4819-131-6-199909210-00022

Download citation file:

© 2020

×
Permissions

Published: Ann Intern Med. 1999;131(6):476.

DOI: 10.7326/0003-4819-131-6-199909210-00022

©
1999 American College of Physicians
0 Citations
CONTINUE WITH LIMITED ACCESS
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×
acp link acp
silverchair link silverchair

Copyright © 2020 American College of Physicians. All Rights Reserved.

Print ISSN: 0003-4819 | Online ISSN: 1539-3704

Privacy Policy

|

Conditions of Use

This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy. | Accept
×

You need a subscription to this content to use this feature.

×
PDF Downloads Require Access to the Full Article.
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×
Access to this Free Content Requires Users to be Registered and Logged In. Please Choose One of the Following Options
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×