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Letters |21 September 1999

Hemochromatosis and Vitamin C

James C. Barton, MD; Paul C. Adams, MD; Lawrie W. Powell, MD, PhD

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Author, Article, and Disclosure Information
  • Southern Iron Disorders Center; Birmingham, AL 35209 (Barton)
    London Health Sciences Center; London, Ontario N6A 5A5, Canada (Adams)
    Queensland Institute of Medical Research, University of Queensland; Brisbane 4029 QLD, Australia (Powell)
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In persons who have thalassemia major with iron overload, vitamin C (ascorbic acid) can mobilize iron stored in reticuloendothelial cells, sometimes leading to acute cardiac toxicity (1). Withdrawal of vitamin C supplementation has been associated with improvement of left ventricular function, and vitamin C deficiency may protect against the cardiac effects of iron overload in patients with thalassemia major (1). In contrast, there is little published evidence that vitamin C mobilizes large quantities of iron or induces acute (or chronic) toxicity in hemochromatosis. Urinary iron excretion, a measure of iron mobilization, was not increased by oral...
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Barton JC, Adams PC, Powell LW. Hemochromatosis and Vitamin C. Ann Intern Med. 1999;131:476. doi: 10.7326/0003-4819-131-6-199909210-00022

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Published: Ann Intern Med. 1999;131(6):476.

DOI: 10.7326/0003-4819-131-6-199909210-00022

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1999 American College of Physicians
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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