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Letters |21 December 1999

Saquinavir-Induced Hypoglycemia in Type 2 Diabetes

Oren Zimhony, MD; David Stein, MD

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Author, Article, and Disclosure Information
  • Albert Einstein College of Medicine; Bronx, NY 10461 (Zimhony)
    Jacobi Medical Center; Bronx, NY 10461 (Stein)
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TO THE EDITOR:
Worsening hyperglycemia and new-onset diabetes have been reported in patients taking all of the available protease inhibitors (1). However, hypoglycemia has also been associated with saquinavir use (2, 3).
A 49-year-old HIV-infected man taking insulin (Humulin 70/30, Eli Lilly and Co., Indianapolis, Indiana), 40 U/d, for type 2 diabetes had dizziness 6 weeks after his HIV therapy was changed. A new regimen that included stavudine, 40 mg twice daily; didanosine, 200 mg twice daily; and saquinavir, 1200 mg three times daily, in the form of soft gelatin capsules, was started. Eight weeks after this change,...
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Zimhony O, Stein D. Saquinavir-Induced Hypoglycemia in Type 2 Diabetes. Ann Intern Med. 1999;131:980. doi: https://doi.org/10.7326/0003-4819-131-12-199912210-00019

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Published: Ann Intern Med. 1999;131(12):980.

DOI: 10.7326/0003-4819-131-12-199912210-00019

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1999 American College of Physicians
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