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Letters |21 December 1999

Saquinavir-Induced Hypoglycemia in Type 2 Diabetes

Oren Zimhony, MD; David Stein, MD

Article, Author, and Disclosure Information
Author, Article, and Disclosure Information
  • Albert Einstein College of Medicine; Bronx, NY 10461 (Zimhony)
    Jacobi Medical Center; Bronx, NY 10461 (Stein)
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TO THE EDITOR:
Worsening hyperglycemia and new-onset diabetes have been reported in patients taking all of the available protease inhibitors (1). However, hypoglycemia has also been associated with saquinavir use (2, 3).
A 49-year-old HIV-infected man taking insulin (Humulin 70/30, Eli Lilly and Co., Indianapolis, Indiana), 40 U/d, for type 2 diabetes had dizziness 6 weeks after his HIV therapy was changed. A new regimen that included stavudine, 40 mg twice daily; didanosine, 200 mg twice daily; and saquinavir, 1200 mg three times daily, in the form of soft gelatin capsules, was started. Eight weeks after this change, the patient fainted at work. On arrival at the emergency department, his blood glucose level was 24 mg/dL. He was instructed to administer 20 U of insulin daily and was discharged. Despite the decrease in insulin dosage, the patient continued to have frequent dizziness and low blood glucose levels; insulin therapy was therefore discontinued.
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Zimhony O, Stein D. Saquinavir-Induced Hypoglycemia in Type 2 Diabetes. Ann Intern Med. ;131:980. doi: 10.7326/0003-4819-131-12-199912210-00019

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Published: Ann Intern Med. 1999;131(12):980.

DOI: 10.7326/0003-4819-131-12-199912210-00019

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1999 American College of Physicians
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