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Letters |7 November 2000

Coenzyme Q10 and Congestive Heart Failure

Stephen S. Gottlieb, MD; Meenakshi Khatta, MS, CRNP; Michael L. Fisher, MD

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Copyright ©2004 by the American College of Physicians
2004
  • University of Maryland; Baltimore, MD 21201 (Gottlieb, Khatta, Fisher)
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The use of coenzyme Q10 in congestive heart failure continues to be advocated on the basis of anecdotal information and uncontrolled data. Dr. Sinatra's letter uses unsubstantiated theoretical concerns to ignore and discount the implications of a negative controlled trial. It is possible that higher concentrations of a substance might be more beneficial than lower concentrations. Nevertheless, in patients with heart failure, most drugs that are useful at high doses are also effective at lower doses. To use Dr. Sinatra's example, patients receiving angiotensin-converting enzyme inhibitors have fewer hospitalizations when the drug is given at a high...
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Gottlieb SS, Khatta M, Fisher ML. Coenzyme Q10 and Congestive Heart Failure. Ann Intern Med. 2000;133:745–746. doi: 10.7326/0003-4819-133-9-200011070-00021

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Published: Ann Intern Med. 2000;133(9):745-746.

DOI: 10.7326/0003-4819-133-9-200011070-00021

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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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