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Letters |21 November 2000

Acquired C1 Esterase Inhibitor Deficiency

Thomas Grünewald, MD

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Author, Article, and Disclosure Information
Copyright ©2004 by the American College of Physicians
2004
  • Klinikum “St. Georg” Leipzig; D-04129 Leipzig, Germany (Grünewald)
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TO THE EDITOR:
Markovic and colleagues have written an excellent review on angioedema due to acquired C1 esterase inhibitor deficiency (1). However, from a practical standpoint, their proposal for diagnostic work-up in patients with angioedema of unknown cause is of concern: It is time-consuming and expensive to test three complement proteins before determinations of C1 esterase inhibitor activity in patients with suspected angioedema. In addition, C3 and C4 levels may be within normal limits during symptom-free intervals. Therefore, if the algorithm provided is used, some patients may be misdiagnosed. It seems more feasible to first determine C1 esterase inhibitor...
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Grünewald T. Acquired C1 Esterase Inhibitor Deficiency. Ann Intern Med. 2000;133:837. doi: https://doi.org/10.7326/0003-4819-133-10-200011210-00021

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Published: Ann Intern Med. 2000;133(10):837.

DOI: 10.7326/0003-4819-133-10-200011210-00021

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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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