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Letters |2 January 2001

Hormone Therapy and Risk for Venous Thromboembolism: Comments and Correction

Mark R. Goldstein, MD

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  • West Chester, PA 19382 (Goldstein)
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TO THE EDITOR:
Grady and colleagues' interesting report (1) from HERS demonstrated that postmenopausal estrogen and progestin therapy increased the risk for venous thromboembolism nearly threefold in women with established coronary heart disease. Unexpectedly, the risk for venous thromboembolism was decreased by half in the women who were taking statin drugs.
In the original HERS report (2), treatment with estrogen and progestin over a 4.1-year period did not reduce the overall rate of coronary heart disease events despite a favorable effect on lipoproteins. In fact, event rates were significantly higher during the first year in the estrogen–progestin group. This...
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Goldstein MR. Hormone Therapy and Risk for Venous Thromboembolism: Comments and Correction. Ann Intern Med. 2001;134:81. doi: 10.7326/0003-4819-134-1-200101020-00021

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Published: Ann Intern Med. 2001;134(1):81.

DOI: 10.7326/0003-4819-134-1-200101020-00021

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2001 American College of Physicians
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