Shoji Kubo, MD; Shuhei Nishiguchi, MD; Kazuhiro Hirohashi, MD; Hiromu Tanaka, MD; Taichi Shuto, MD; Osamu Yamazaki, MD; Susumu Shiomi, MD; Akihiro Tamori, MD; Hiroko Oka, MD; Sumito Igawa, MD; Tetsuo Kuroki, MD; Hiroaki Kinoshita, MD
†Deceased.
Acknowledgments: The authors thank Daniel K. Podolsky, MD, of Massachusetts General Hospital, Harvard Medical School, for critical reading of the manuscript and Hiroyuki Yasuda for statistical analysis.
Grant Support: In part by grants from the Ministry of Education, Science, Sports, and Culture (09671330) and the Ministry of Health and Welfare, Japan.
Requests for Single Reprints: Shuhei Nishiguchi, MD, Third Department of Internal Medicine, Osaka City University Medical School, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan; e-mail, snishiguch@med.osaka-cu.ac.jp.
Current Author Addresses: Drs. Kubo, Hirohashi, Tanaka, Shuto, and Kinoshita: Second Department of Surgery, Osaka City University Medical School, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan.
Drs. Nishiguchi, Shiomi, and Tamori: Third Department of Internal Medicine, Osaka City University Medical School, 1-4-3 Asahimachi, Abeno-ku, Osaka 545 8585, Japan.
Dr. Yamazaki: Department of General and Gastrointestinal Surgery, Osaka City General Hospital, 2-13-22 Miyakojimahondori, Miyakojima-ku, Osaka 534-0021, Japan.
Dr. Oka: Department of Gastroenterology, Osaka City General Hospital, 2-13-22 Miyakojimahondori, Miyakojima-ku, Osaka 534-0021, Japan.
Dr. Igawa: Joto Central Hospital, 5-13-47 Shiginonishi, Joto-ku, Osaka 536-0014, Japan.
Author Contributions: Conception and design: S. Kubo, S. Nishiguchi, T. Kuroki, H. Kinoshita.
Analysis and interpretation of the data: S. Kubo, T. Kuroki, S. Nishiguchi.
Drafting of the article: S. Kubo.
Critical revision of the article for important intellectual content: S. Nishiguchi.
Final approval of the article: S. Kubo, S. Nishiguchi, K. Hirohashi, H. Tanaka, T. Shuto, O. Yamazaki, S. Shiomi, A. Tamori, H. Oka, S. Igawa, H. Kinoshita.
Provision of study materials or patients: S. Kubo, S. Nishiguchi, K. Hirohashi, H. Tanaka, T. Shuto, O. Yamazaki, S. Shiomi, A. Tamori, H. Oka, S. Igawa, T. Kuroki, H. Kinoshita.
Statistical expertise: S. Kubo, S. Nishiguchi.
Obtaining of funding: S. Kubo, H. Kinoshita.
Administrative, technical, or logistic support: S. Kubo, S. Nishiguchi, K. Hirohashi, H. Tanaka, T. Shuto, O. Yamazaki, S. Shiomi, A. Tamori, H. Oka, S. Igawa, T. Kuroki.
Collection and assembly of data: S. Kubo, S. Nishiguchi, K. Hirohashi, H. Tanaka, O. Yamazaki, S. Shiomi, A. Tamori, H. Oka, S. Igawa.
Interferon therapy decreases the incidence of hepatocellular carcinoma in patients with chronic hepatitis C.
To evaluate effects of interferon-α on recurrence after resection of hepatitis C virus–related hepatocellular carcinoma.
Randomized, controlled trial.
University hospital, medical center, and affiliated hospital in Osaka, Japan.
30 men were randomly allocated after resection to the interferon-α group (n = 15) or the control group (n = 15).
Patients in the interferon-α group received interferon-α, 6 MIU intramuscularly daily for 2 weeks, then three times weekly for 14 weeks, and finally twice weekly for 88 weeks.
Recurrence rates after resection.
Recurrent tumors were detected in 5 patients in the interferon-α group and in 12 control patients. The recurrence rate was significantly lower in the interferon-α group than in the control group (P = 0.037).
Postoperative interferon-α therapy appears to decrease recurrence after resection of hepatitis C virus–related hepatocellular carcinoma.
Kubo S, Nishiguchi S, Hirohashi K, et al. Effects of Long-Term Postoperative Interferon-α Therapy on Intrahepatic Recurrence after Resection of Hepatitis C Virus–Related Hepatocellular Carcinoma: A Randomized, Controlled Trial. Ann Intern Med. 2001;134:963–967. doi: https://doi.org/10.7326/0003-4819-134-10-200105150-00010
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© 2019
Published: Ann Intern Med. 2001;134(10):963-967.
DOI: 10.7326/0003-4819-134-10-200105150-00010
Gastroenterology/Hepatology, Gastrointestinal Cancer, Hematology/Oncology, Infectious Disease, Liver Cancer.
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