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Letters |3 July 2001

Testosterone and Resistance Training in AIDS

Steven K. Grinspoon, MD

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  • Harvard Medical School; Boston, MA 02108 (Grinspoon)
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We agree with Dr. Kamel that our data demonstrate a significant effect of supraphysiologic testosterone on muscle mass and strength in eugonadal men with AIDS wasting. The use of testosterone may therefore be considered to reverse sarcopenia in this population. However, we also agree that the long-term safety of supraphysiologic testosterone is unknown in this population. Although our data do not show adverse effects on prostate-specific antigen and hematocrit levels, the study was short and the longer-term safety effects remain unknown. Furthermore, our data do suggest a decrease in high-density lipoprotein cholesterol level, which may adversely affect such...
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Grinspoon SK. Testosterone and Resistance Training in AIDS. Ann Intern Med. 2001;135:65. doi: 10.7326/0003-4819-135-1-200107030-00028

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Published: Ann Intern Med. 2001;135(1):65.

DOI: 10.7326/0003-4819-135-1-200107030-00028

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2001 American College of Physicians
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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