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Letters |4 December 2001

Albumin Meta-Analysis

Mahlon M. Wilkes, PhD; Roberta J. Navickis, PhD

Article, Author, and Disclosure Information
Author, Article, and Disclosure Information
  • Hygeia Associates; Grass Valley, CA 95949
    Note: The authors also acknowledged in their cover letter that they had served as consultants to the Plasma Protein Products Therapeutics Association. They further disclosed that they otherwise held no financial interest of any kind in the Plasma Protein Therapeutics Association, any albumin products, or products competing with albumin.—The Editor
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IN RESPONSE:
Gibney asserts that our meta-analysis “fails to demonstrate indications for colloid” and was biased in favor of albumin therapy because of industry funding. Our meta-analysis addressed albumin safety broadly, in the context of a previous meta-analysis suggesting excess albumin-associated mortality (1). We did not try to assess the efficacy of albumin therapy for particular indications. Optimally, such an assessment would encompass additional clinically relevant end points, such as morbidity and length of stay, rather than solely mortality, which is a comparatively insensitive end point in large populations of acutely ill patients. In several randomized trials, significant differences between albumin and control groups could be demonstrated with respect to morbidity or length of stay but not mortality (2–5).
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Wilkes MM, Navickis RJ. Albumin Meta-Analysis. Ann Intern Med. ;135:1009. doi: 10.7326/0003-4819-135-11-200112040-00024

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Published: Ann Intern Med. 2001;135(11):1009.

DOI: 10.7326/0003-4819-135-11-200112040-00024

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2001 American College of Physicians
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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