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Letters |6 August 2002

Tetany Secondary to the Use of a Proton-Pump Inhibitor

Vishakalakshmi Subbiah, MBBS; John A. Tayek, MS, MD

Article, Author, and Disclosure Information
Author, Article, and Disclosure Information
  • Harbor–UCLA Medical Center; Torrance, CA 90509

    Grant Support: By the U.S. National Institutes of Health Clinical Investigator Award KO8DK02083 and MO1-RR-00425.

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TO THE EDITOR:
Calcium is well absorbed in the presence of acid, but absorption is decreased by 80% in patients with achlorhydria (1). Six years after near total thyroidectomy, a 46-year-old woman presented to her primary care physician with symptoms of heartburn. Gastroesophageal reflux disease was diagnosed, and the patient was prescribed ranitidine, 150 mg orally twice per day. After 3 months of persistent gastroesophageal reflux disease, her symptoms were relieved with a proton-pump inhibitor (lansoprazole, 30 mg).
Approximately 2 weeks after treatment with the proton-pump inhibitor, the patient reported numbness, chest pressure, and muscle cramping in the hands...
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Subbiah V, Tayek JA. Tetany Secondary to the Use of a Proton-Pump Inhibitor. Ann Intern Med. 2002;137:219. doi: 10.7326/0003-4819-137-3-200208060-00024

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Published: Ann Intern Med. 2002;137(3):219.

DOI: 10.7326/0003-4819-137-3-200208060-00024

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2002 American College of Physicians
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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