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Letters |17 September 2002

Long-Term Outcome in Lupus Nephritis

Gabor G. Illei, MD; James E. Balow, MD; Dimitrios T. Boumpas, MD

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  • National Institutes of Health; Bethesda, MD 20892
    University of Crete Medical School; Heraklion 711 10, Greece
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We agree with Spiera and colleagues that the larger number of deaths in the cyclophosphamide-containing groups in our study is intriguing and that a survival analysis is the optimal statistical method to determine whether there is a true difference in mortality. However, we believe that combining the mortality data from both cyclophosphamide-containing groups and comparing them with the methylprednisolone group is flawed because this method assumes that any increased mortality in the combination group is attributable to cyclophosphamide. Comparing the methylprednisolone-only group with the cyclophosphamide-only group in a Breslow-Gehan-Wilcoxon survival analysis showed no significant difference in risk for...
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Illei GG, Balow JE, Boumpas DT. Long-Term Outcome in Lupus Nephritis. Ann Intern Med. 2002;137:545–546. doi: 10.7326/0003-4819-137-6-200209170-00019

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Published: Ann Intern Med. 2002;137(6):545-546.

DOI: 10.7326/0003-4819-137-6-200209170-00019

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2002 American College of Physicians
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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