Mark A. Crowther, MD; John G. Kelton, MD
Grant Support: Some of the studies cited in this report were funded by research grants from the Heart and Stroke Foundation of Ontario. Dr. Crowther holds a Canadian Institute of Health Research Scholarship. Dr. Kelton holds a Canada Research Chair.
Requests for Single Reprints: Mark A Crowther, MD, St. Joseph's Hospital, Room L208, 50 Charlton Avenue East, Hamilton, Ontario L8N 4A6, Canada.
Current Author Addresses: Dr. Crowther: St. Joseph's Hospital, Room L208, 50 Charlton Avenue East, Hamilton, Ontario L8N 4A6, Canada.
Dr. Kelton: McMaster University Medical Centre, Room 3W10, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada.
Congenital causes of venous thrombosis have gained increasing prominence with the description of the factor V Leiden mutation and the prothrombin gene mutation. More recently, the description of the association between increased levels of coagulation factors and venous thrombosis and the finding that patients with thrombophilia can harbor more than one prothrombotic state have further increased the clinical relevance of the congenital thrombophilic states. In this qualitative review, we summarize current knowledge of the congenital prothrombotic states and propose a simple classification system that divides the states into two broad groups: those associated with reduced levels of the inhibitors of the coagulation cascade and those associated with increased levels or function of the coagulation factors. The first group is less common than the second, but it is associated with a much higher risk for venous thrombosis. This review provides clinicians with an evidence-based, practical guide to the congenital prothrombotic states.
Crowther MA, Kelton JG. Congenital Thrombophilic States Associated with Venous Thrombosis: A Qualitative Overview and Proposed Classification System. Ann Intern Med. 2003;138:128–134. doi: https://doi.org/10.7326/0003-4819-138-2-200301210-00014
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Published: Ann Intern Med. 2003;138(2):128-134.
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