Thomas A. Barringer, MD; Julienne K. Kirk, PharmD; Amy C. Santaniello, PharmD; Kristie Long Foley, PhD; Robert Michielutte, PhD
Acknowledgments: The authors thank Dave Reboussin, PhD, for his assistance in the statistical analysis. Dr. Barringer thanks Geraldine D. Anastasio, PharmD, his original co-investigator who initiated the research project, for her enthusiasm and encouragement to continue the study in her absence.
Grant Support: By the Charlotte-Mecklenburg Health Services Foundation, an independent, charitable foundation that supports medical education and research within the Carolinas HealthCare System.
Potential Financial Conflicts of Interest: None disclosed.
Requests for Single Reprints: Thomas A. Barringer, MD, Department of Family Practice, Carolinas Medical Center, CMC-MP Building, 1350 South Kings Drive, Charlotte, NC 28207; e-mail, firstname.lastname@example.org.
Current Author Addresses: Dr. Barringer: Department of Family Practice, Carolinas Medical Center, CMC-MP Building, 1350 South Kings Drive, Charlotte, NC 28207.
Drs. Kirk and Michielutte: Department of Family Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157.
Dr. Santaniello: 8918 Waltham Forest Court, Waxhaw, NC 28173.
Dr. Foley: Department of Public Health Sciences, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157.
Author Contributions: Conception and design: T.A. Barringer, J.K. Kirk.
Analysis and interpretation of the data: T.A. Barringer, J.K. Kirk, K.L. Foley, R. Michielutte.
Drafting of the article: T.A. Barringer, J.K. Kirk, A.C. Santaniello, K.L. Foley.
Critical revision of the article for important intellectual content: T.A. Barringer, J.K. Kirk, K.L. Foley, R. Michielutte.
Final approval of the article: T.A. Barringer, J.K. Kirk, A.C. Santaniello, R. Michielutte.
Provision of study materials or patients: T.A. Barringer, J.K. Kirk, A.C. Santaniello.
Statistical expertise: T.A. Barringer, K.L. Foley, R. Michielutte.
Obtaining of funding: T.A. Barringer.
Administrative, technical, or logistic support: T.A. Barringer, J.K. Kirk.
Collection and assembly of data: T.A. Barringer, J.K. Kirk, A.C. Santaniello.
Use of multivitamin and mineral supplements is common among U.S. adults, yet few well-designed trials have assessed the reputed benefits.
To determine the effect of a daily multivitamin and mineral supplement on infection and well-being.
Randomized, double-blind, placebo-controlled trial.
Primary care clinics at two medical centers in North Carolina.
130 community-dwelling adults stratified by age (45 to 64 years or 65 years) and presence of type 2 diabetes mellitus.
Multivitamin and mineral supplement or placebo taken daily for 1 year.
Incidence of participant-reported symptoms of infection, incidence of infection-associated absenteeism, and scores on the physical and mental health subscales of the Medical Outcomes Study 12-Item Short Form.
More participants receiving placebo reported an infectious illness over the study year than did participants receiving multivitamin and mineral supplements (73% vs. 43%; P < 0.001). Infection-related absenteeism was also higher in the placebo group than in the treatment group (57% vs. 21%; P < 0.001). Participants with type 2 diabetes mellitus (n = 51) accounted for this finding. Among diabetic participants receiving placebo, 93% reported an infection compared with 17% of those receiving supplements (P < 0.001). Medical Outcomes Study 12-Item Short Form scores did not differ between the treatment and placebo groups.
A multivitamin and mineral supplement reduced the incidence of participant-reported infection and related absenteeism in a sample of participants with type 2 diabetes mellitus and a high prevalence of subclinical micronutrient deficiency. A larger clinical trial is needed to determine whether these findings can be replicated not only in diabetic persons but also in any population with a high rate of suboptimal nutrition or potential underlying disease impairment.
Barringer TA, Kirk JK, Santaniello AC, et al. Effect of a Multivitamin and Mineral Supplement on Infection and Quality of Life: A Randomized, Double-Blind, Placebo-Controlled Trial. Ann Intern Med. 2003;138:365–371. doi: 10.7326/0003-4819-138-5-200303040-00005
Download citation file:
Published: Ann Intern Med. 2003;138(5):365-371.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
Results provided by:
Copyright © 2019 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use