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Letters |16 March 2004

Randomized Trial of Warfarin Nomograms

Theodore E. Warkentin, MD

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Author, Article, and Disclosure Information
  • From Hamilton General Hospital, Hamilton, Ontario L8L 2X2, Canada.
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TO THE EDITOR:
In their randomized, double-blind trial, Kovacs and colleagues (1) concluded that loading doses of warfarin (10 mg on 2 consecutive days) are more effective than standard dosing (5 mg on 2 consecutive days) in achieving therapeutic INR values among outpatients with deep venous thrombosis who were receiving at least 5 days of therapy with low-molecular-weight heparin. However, the authors have not adequately established the safety of this approach, particularly with respect to avoiding prothrombotic complications of warfarin. Among their study's end points, the authors did not list 2 such sequelae: warfarin-induced skin necrosis and warfarin-induced venous limb...
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Warkentin TE. Randomized Trial of Warfarin Nomograms. Ann Intern Med. 2004;140:490–491. doi: 10.7326/0003-4819-140-6-200403160-00028

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Published: Ann Intern Med. 2004;140(6):490-491.

DOI: 10.7326/0003-4819-140-6-200403160-00028

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2004 American College of Physicians
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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