Skip Navigation
Menu
Reviews |20 April 2004

Alzheimer Disease: Mechanistic Understanding Predicts Novel Therapies

Dennis J. Selkoe, MD

Article, Author, and Disclosure Information
Author, Article, and Disclosure Information
  • From Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts.

    For definition of terms used, see Glossary.

    Acknowledgments: The author thanks his colleagues and collaborators for many helpful discussions.

    Grant Support: By the National Institutes of Health, Alzheimer's Association, and the Foundation for Neurologic Diseases. Dr. Selkoe is a founding scientist of Athena Neurosciences, now Elan Corporation.

    Potential Financial Conflicts of Interest:Honoraria and Patents received: Elan Corp.

    Requests for Single Reprints: Dennis J. Selkoe, MD, Center for Neurologic Diseases, Brigham and Women's Hospital, 77 Avenue Louis Pasteur, HIM 730, Boston, MA 02115.


PHYSIOLOGY IN MEDICINE: A SERIES OF ARTICLES LINKING MEDICINE WITH SCIENCE
Co-sponsored by the American College of Physicians and the American Physiological Society
Physiology in Medicine: Dennis A. Ausiello, MD, Editor; Dale J. Benos, PhD, Deputy Editor; Francois Abboud, MD, Associate Editor; William J. Koopman, MD, Associate Editor
Annals of Internal Medicine: Paul Epstein, MD, Series Editor
×
FULL TEXT
PHYSIOLOGY IN MEDICINE: A SERIES OF ARTICLES LINKING MEDICINE WITH SCIENCE
Co-sponsored by the American College of Physicians and the American Physiological Society
Physiology in Medicine: Dennis A. Ausiello, MD, Editor; Dale J. Benos, PhD, Deputy Editor; Francois Abboud, MD, Associate Editor; William J. Koopman, MD, Associate Editor
Annals of Internal Medicine: Paul Epstein, MD, Series Editor
Alzheimer disease usually begins with gradual failure of recent memory with preserved alertness and motor function.
The syndrome of minimal cognitive impairment (mild cognitive impairment)—a subtle decrease in short-term declarative memory with otherwise normal cognition—is often a harbinger of Alzheimer disease.
Alzheimer disease...
FULL TEXT
PDF
Not Available
Citations
Citation

Selkoe DJ. Alzheimer Disease: Mechanistic Understanding Predicts Novel Therapies. Ann Intern Med. 2004;140:627–638. doi: 10.7326/0003-4819-140-8-200404200-00047

Download citation file:

© 2019

×
Permissions

Published: Ann Intern Med. 2004;140(8):627-638.

DOI: 10.7326/0003-4819-140-8-200404200-00047

©
2004 American College of Physicians
298 Citations

Related Articles
Amyloid-β (1-40) and Mortality in Patients With Non–ST-Segment Elevation Acute Coronary Syndrome: A Cohort Study
Annals of Internal Medicine; 168 (12): 855-865
Pharmacologic Interventions to Prevent Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer-Type Dementia: A Systematic Review
Annals of Internal Medicine; 168 (1): 39-51
Over-the-Counter Supplement Interventions to Prevent Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer-Type Dementia: A Systematic Review
Annals of Internal Medicine; 168 (1): 52-62
Annals for Educators - 2 January 2018
Annals of Internal Medicine; 168 (1): ED1
View MoreView Less

Journal Club
Review: Statins are not associated with cognitive impairment, Alzheimer disease, or dementia
Annals of Internal Medicine; 160 (10): JC10
A 12-month, in-home exercise program delayed functional deterioration in Alzheimer disease
Annals of Internal Medicine; 159 (4): JC10
Ginkgo biloba extract did not reduce risk for Alzheimer disease in elderly patients with memory complaints
Annals of Internal Medicine; 158 (2): JC7
Donepezil or memantine improved cognitive functioning in moderate-to-severe Alzheimer disease
Annals of Internal Medicine; 156 (12): JC6-10
View MoreView Less

Related Point of Care
Dementia
Annals of Internal Medicine; 161 (3): ITC1
View MoreView Less

Related Topics
Dementia
Neurology

Dementia, Neurology.

PubMed Articles
Effects of Alzheimer's Disease and Lewy Body Disease on Subcortical Atrophy.
Eur J Neurol 2019.
Bringing Order out of Chaos: Establishing an Epistatic Relationship between CD33 and TREM2.
Neuron 2019;103(5):747-749.
View More

Results provided by: PubMed

CONTINUE WITH LIMITED ACCESS
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×
acp link acp
silverchair link silverchair

Copyright © 2019 American College of Physicians. All Rights Reserved.

Print ISSN: 0003-4819 | Online ISSN: 1539-3704

Privacy Policy

|

Conditions of Use

This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy. | Accept
×

You need a subscription to this content to use this feature.

×
PDF Downloads Require Access to the Full Article.
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×
Access to this Free Content Requires Users to be Registered and Logged In. Please Choose One of the Following Options
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×