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Reviews |20 April 2004

Alzheimer Disease: Mechanistic Understanding Predicts Novel Therapies

Dennis J. Selkoe, MD

Article, Author, and Disclosure Information
Author, Article, and Disclosure Information
  • From Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts.

    For definition of terms used, see Glossary.

    Acknowledgments: The author thanks his colleagues and collaborators for many helpful discussions.

    Grant Support: By the National Institutes of Health, Alzheimer's Association, and the Foundation for Neurologic Diseases. Dr. Selkoe is a founding scientist of Athena Neurosciences, now Elan Corporation.

    Potential Financial Conflicts of Interest:Honoraria and Patents received: Elan Corp.

    Requests for Single Reprints: Dennis J. Selkoe, MD, Center for Neurologic Diseases, Brigham and Women's Hospital, 77 Avenue Louis Pasteur, HIM 730, Boston, MA 02115.


PHYSIOLOGY IN MEDICINE: A SERIES OF ARTICLES LINKING MEDICINE WITH SCIENCE
Co-sponsored by the American College of Physicians and the American Physiological Society
Physiology in Medicine: Dennis A. Ausiello, MD, Editor; Dale J. Benos, PhD, Deputy Editor; Francois Abboud, MD, Associate Editor; William J. Koopman, MD, Associate Editor
Annals of Internal Medicine: Paul Epstein, MD, Series Editor
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FULL TEXT
PHYSIOLOGY IN MEDICINE: A SERIES OF ARTICLES LINKING MEDICINE WITH SCIENCE
Co-sponsored by the American College of Physicians and the American Physiological Society
Physiology in Medicine: Dennis A. Ausiello, MD, Editor; Dale J. Benos, PhD, Deputy Editor; Francois Abboud, MD, Associate Editor; William J. Koopman, MD, Associate Editor
Annals of Internal Medicine: Paul Epstein, MD, Series Editor
Alzheimer disease usually begins with gradual failure of recent memory with preserved alertness and motor function.
The syndrome of minimal cognitive impairment (mild cognitive impairment)—a subtle decrease in short-term declarative memory with otherwise normal cognition—is often a harbinger of Alzheimer disease.
Alzheimer disease progresses slowly to involve many cognitive spheres and shortens life expectancy, with most patients ultimately dying of secondary respiratory complications (for example, aspiration and pneumonia).
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Selkoe DJ. Alzheimer Disease: Mechanistic Understanding Predicts Novel Therapies. Ann Intern Med. ;140:627–638. doi: 10.7326/0003-4819-140-8-200404200-00047

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Published: Ann Intern Med. 2004;140(8):627-638.

DOI: 10.7326/0003-4819-140-8-200404200-00047

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2004 American College of Physicians
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