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Letters |20 April 2004

Retrobulbar Optic Neuritis Associated with Infliximab in a Patient with Crohn Disease

Betsy Y.C. Strong, MD; Barbara C. Erny, MD; Howard Herzenberg, MD; Kristen J. Razzeca, MD

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  • From Camino Medical Group, Sunnyvale, CA 94086.
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TO THE EDITOR:
Case Report: A 45-year-old woman with type 2 diabetes mellitus and Crohn disease developed retrobulbar optic neuritis that was temporally associated with infliximab treatment. Three years earlier, she had Bell palsy, which resolved. Two years earlier, she received a diagnosis of Crohn disease and nongranulomatous uveitis. She responded initially to prednisone and mesalamine, but her condition later worsened, and she developed an enterovaginal fistula. She responded well to azathioprine; intravenous antibiotics; intravenous corticosteroids; and infliximab, 5 mg/kg of body weight. She continued to take infliximab every other month, and corticosteroids were successfully withdrawn.
A week after the...
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Strong BY, Erny BC, Herzenberg H, et al. Retrobulbar Optic Neuritis Associated with Infliximab in a Patient with Crohn Disease. Ann Intern Med. 2004;140:W–34. doi: 10.7326/0003-4819-140-8-200404200-00037-w4

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Published: Ann Intern Med. 2004;140(8):W-34.

DOI: 10.7326/0003-4819-140-8-200404200-00037-w4

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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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