High-Dosage Vitamin E Supplementation and All-Cause Mortality

Connie Marras; Anthony E. Lang; David Oakes; Michael P. McDermott; Karl Kieburtz; Ira Shoulson; Caroline M. Tanner; Stanley Fahn

doi:10.7326/0003-4819-143-2-200507190-00022

Letters |19 July 2005

High-Dosage Vitamin E Supplementation and All-Cause Mortality

Connie Marras, MD; Anthony E. Lang, MD; David Oakes, PhD; Michael P. McDermott, PhD; Karl Kieburtz, MD, MPH; Ira Shoulson, MD; Caroline M. Tanner, MD, PhD; Stanley Fahn, MD

Connie Marras, MD

From the University of Toronto, Toronto, Ontario MST 258, Canada; University of Rochester Medical Center, Rochester, NY 14642; The Parkinson's Institute, Sunnyvale, CA 94809-1605; and Columbia University, New York, NY 10032.

Anthony E. Lang, MD

David Oakes, PhD

Michael P. McDermott, PhD

Karl Kieburtz, MD, MPH

Ira Shoulson, MD

Caroline M. Tanner, MD, PhD

Stanley Fahn, MD

Article, Author, and Disclosure Information

TO THE EDITOR:

In a meta-analysis of selected randomized trials, Miller and colleagues (1) found an increase in all-cause mortality associated with high-dosage vitamin E supplementation for at least 1 year (1). Their analysis included the DATATOP study, a randomized, placebo-controlled trial of selegiline and vitamin E in 800 patients with early Parkinson disease (2). In the DATATOP trial, 399 of 800 participants were randomly assigned to receive 2000 IU of vitamin E per day, the highest dosage studied in Miller and colleagues' meta-analysis. Median duration of vitamin E exposure during the randomized phase was 2.6 years. We have now accrued 13 years of follow-up and have documented 296 deaths compared with the 137 DATATOP deaths incorporated into Miller and colleagues' meta-analysis (3).

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2005 American College of Physicians

Letters |19 July 2005

High-Dosage Vitamin E Supplementation and All-Cause Mortality

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Letters |19 July 2005

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