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Letters |19 July 2005

High-Dosage Vitamin E Supplementation and All-Cause Mortality

Simin Nikbin Meydani, DVM, PhD; Joseph Lau, MD; Gerard E. Dallal, PhD; Mohsen Meydani, DVM, PhD

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  • From Tufts University, Boston, MA 02111.

    Potential Financial Conflicts of Interest: None disclosed.

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TO THE EDITOR:
Miller and colleagues (1) reported that supplemental intake of vitamin E at dosages greater than 150 IU/d progressively increases all-cause mortality. There are several problems with their analysis and interpretation of the data. The harmful effect above 150 IU/d is an artifact of the model they chose to fit. When researchers fit a quadratic-linear spline, the result must be a quadratic-linear spline regardless of whether the data behave that way. In another reasonable model, the favorable response to vitamin E is constant until a certain dose, above which the change in all-cause mortality risk difference...
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Meydani SN, Lau J, Dallal GE, et al. High-Dosage Vitamin E Supplementation and All-Cause Mortality. Ann Intern Med. 2005;143:153. doi: https://doi.org/10.7326/0003-4819-143-2-200507190-00023

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Published: Ann Intern Med. 2005;143(2):153.

DOI: 10.7326/0003-4819-143-2-200507190-00023

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2005 American College of Physicians
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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