Skip Navigation
Menu
Letters |18 October 2005

The Risk for Myocardial Infarction with Cyclooxygenase-2 Inhibitors

James M. Brophy, MD, PhD; Linda E. Lévesque, BScPhm, MSc; Bin Zhang, MSc

Article, Author, and Disclosure Information
Author, Article, and Disclosure Information
  • From McGill University, Montréal, Québec H3A 1A1, Canada.

    Potential Financial Conflicts of Interest: None disclosed.

×
FULL TEXT
IN RESPONSE:
We agree with Kim and colleagues that, while celecoxib appears to be less cardiotoxic than rofecoxib in several observational studies (1-3), there is nevertheless reason for concern—particularly when the drug is given in higher doses (as in the APC trial) or in the largely unstudied group of patients with previous myocardial infarctions. We also agree that any cardioprotective benefits of aspirin in rofecoxib users may be offset by a significant reduction in gastrointestinal protection.
As Pijak and colleagues point out, the exact cardioprotective mechanism of aspirin and its potential interaction with COX-2 inhibitors is far from established...
FULL TEXT
PDF
Not Available
Citations
Citation

Brophy JM, Lévesque LE, Zhang B. The Risk for Myocardial Infarction with Cyclooxygenase-2 Inhibitors. Ann Intern Med. 2005;143:617–618. doi: https://doi.org/10.7326/0003-4819-143-8-200510180-00023

Download citation file:

© 2019

×
Permissions

Published: Ann Intern Med. 2005;143(8):617-618.

DOI: 10.7326/0003-4819-143-8-200510180-00023

©
2005 American College of Physicians
0 Citations
CONTINUE WITH LIMITED ACCESS
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×
acp link acp
silverchair link silverchair

Copyright © 2019 American College of Physicians. All Rights Reserved.

Print ISSN: 0003-4819 | Online ISSN: 1539-3704

Privacy Policy

|

Conditions of Use

This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy. | Accept
×

You need a subscription to this content to use this feature.

×
PDF Downloads Require Access to the Full Article.
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×
Access to this Free Content Requires Users to be Registered and Logged In. Please Choose One of the Following Options
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×