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ACP Journal Club |20 May 2008

Testosterone supplementation did not prevent cognitive decline or increase bone mineral density in older men

Eef Hogervorst, PhD

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Similar to most studies investigating sex steroids and cognitive function in older men and women, the trial by Emmelot-Vonk and colleagues has some methodological shortcomings (1). Power analyses were based on an expected improvement of 6 words on the memory test, but the basis for this estimate is unclear. Clinicians and patients often claim memory improvement after testosterone treatment, and animal and cell studies also show beneficial effects on brain tissue (1). In this study, hormone-related quality-of-life measures, but not other quality of life or mood scales, improved after administration of testosterone, which has been reputed to mediate...
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Hogervorst E. Testosterone supplementation did not prevent cognitive decline or increase bone mineral density in older men. Ann Intern Med. 2008;148:JC3–4. doi: 10.7326/0003-4819-148-10-200805200-02004

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Published: Ann Intern Med. 2008;148(10):JC3-4.

DOI: 10.7326/0003-4819-148-10-200805200-02004

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