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Letters |19 February 2008

Agranulocytosis Induced by Nonchemotherapy Drugs

Frank Andersohn, MD; Christine Konzen, MD; Edeltraut Garbe, MD, PhD

Article, Author, and Disclosure Information
Author, Article, and Disclosure Information
  • From Bremen Institute for Prevention Research and Social Medicine, 28539 Bremen, Germany, and Charité—Universitaetsmedizin Berlin, 10117 Berlin, Germany.

    Potential Financial Conflicts of Interest: None disclosed.

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Most of the case reports suggested by Dr. Salem and colleagues were already included in our review (n = 10) (1). Six of the suggested reports were excluded because of use of cytotoxic drugs, pancytopenia, or a neutrophil count nadir of 0.5 × 109 cells/L or greater. Only 2 of the listed case reports (on carbutamide and nifedipine) were not identified because they were not listed as case reports in the MEDLINE publication type field. As causality is “possible” in these reports, the inclusion of these cases during the next database update will not cause any change in our Table 2. We believe that the first report of drug-induced agranulocytosis for a drug is most likely to be published in English-language journals with high international impact, and thus, those have been included in our review.
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Andersohn F, Konzen C, Garbe E. Agranulocytosis Induced by Nonchemotherapy Drugs. Ann Intern Med. ;148:320–321. doi: 10.7326/0003-4819-148-4-200802190-00018

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Published: Ann Intern Med. 2008;148(4):320-321.

DOI: 10.7326/0003-4819-148-4-200802190-00018

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2008 American College of Physicians
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