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Letters |15 July 2008

Drawing Conclusions about Short-Term Variability in Liver Function Test Results

Mariana Lazo, MD, ScM; Elizabeth Selvin, PhD, MPH; Jeanne M. Clark, MD, MPH

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  • From Johns Hopkins University, Baltimore, MD 21205.

    Potential Financial Conflicts of Interest: None disclosed.

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IN RESPONSE:
We appreciate the readers' interest in our study. As indicated by Drs. Arora and Triadafilopoulos, because our study was based on a nonrandom sample of the NHANES III population, selection bias remains a possibility. However, even if selection bias were present, it doesn't change the fact that, although sociodemographic and other patient-level characteristics may be associated with the absolute level of liver enzymes, such factors are unlikely to affect variability, which is a biological phenomenon. Indeed, we did not observe differences in estimates of variability by demographic or other patient-level characteristics. We agree that because Asians make up...
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Lazo M, Selvin E, Clark JM. Drawing Conclusions about Short-Term Variability in Liver Function Test Results. Ann Intern Med. 2008;149:145–146. doi: https://doi.org/10.7326/0003-4819-149-2-200807150-00018

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Published: Ann Intern Med. 2008;149(2):145-146.

DOI: 10.7326/0003-4819-149-2-200807150-00018

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2008 American College of Physicians
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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