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ACP Journal Club |18 November 2008

Review: Hemoglobin-based blood substitutes increase mortality and myocardial infarction in surgical, trauma, and stroke settings

Lillian S. Kao, MD; Alexander Gallus, MD

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Natanson C, Kern SJ, Lurie P, Banks SM, Wolfe SM. Cell-free hemoglobin-based blood substitutes and risk of myocardial infarction and death: a meta-analysis. JAMA. 2008;299:2304-12. 18443023

Emergency Med:

Cardiology:

Hematol/Thrombo:

The development of safe and effective blood substitutes has long held allure as an alternative to allogeneic blood transfusions, particularly for patients with hemorrhagic shock. Natanson and colleagues' meta-analysis showed increased relative risks (RRs) for death and MI with HBBSs, and the cumulative meta-analysis suggested a treatment effect as early as 2000. Although critics argue that heterogeneity in HBBSs and controls preclude combining these studies, advocates of meta-analysis defend pooling...
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Kao LS, Gallus A. Review: Hemoglobin-based blood substitutes increase mortality and myocardial infarction in surgical, trauma, and stroke settings. Ann Intern Med. 2008;149:JC5–4. doi: https://doi.org/10.7326/0003-4819-149-10-200811180-02004

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Published: Ann Intern Med. 2008;149(10):JC5-4.

DOI: 10.7326/0003-4819-149-10-200811180-02004

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