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ACP Journal Club |16 December 2008

A combination of telmisartan and ramipril increased renal outcomes in vascular disease or diabetes

Arsh K. Jain, MD; Matthew A. Weir, MD

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Mann JF, Schmieder RE, McQueen M, et al. Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial. Lancet. 2008;372:547-53. 18707986

Cardiology:

Nephrology:

The large multicenter ONTARGET trial by Mann and colleagues compared combination angiotensin-converting enzyme (ACE) inhibitor and angiotensin-receptor blocker (ARB) therapy with either drug alone for cardiovascular events in patients with coronary artery disease (CAD) or diabetes and ≥ 1 other risk factor for CAD. Combination therapy did not provide benefit over monotherapy for the composite of renal outcomes. As well, the ARB and ACE inhibitor...
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Jain AK, Weir MA. A combination of telmisartan and ramipril increased renal outcomes in vascular disease or diabetes. Ann Intern Med. 2008;149:JC6–7. doi: 10.7326/0003-4819-149-12-200812160-02007

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Published: Ann Intern Med. 2008;149(12):JC6-7.

DOI: 10.7326/0003-4819-149-12-200812160-02007

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