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Letters |6 January 2009

Heterologous Fat Transplantation for the Treatment of HIV-Related Facial Lipoatrophy

Giovanni Guaraldi, MD; Nicola Squillace, MD; Domenico De Fazio, MD; Tullio Prestileo, MD; Frank Palella, MD

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Potential Financial Conflicts of Interest: None disclosed.
  • From the University of Modena and Reggio Emilia, 41100 Modena, Italy; Casa Di Cura Salus Hospital, 42100 Reggio Emilia, Italy; Casa del Sole Hospital, 90100 Palermo, Italy; and Northwestern University Feinberg School of Medicine, Chicago, IL 60610.
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Potential Financial Conflicts of Interest: None disclosed.
Background: Clinical features of HIV-1–related lipodystrophy prominently include facial lipoatrophy. These abnormalities can adversely affect the psychological well-being of HIV-infected individuals, affecting adherence to antiretroviral drug regimens, body self-image, and overall quality of life (1, 2).
Objective: To evaluate heterologous fat transplant to treat facial lipoatrophy in a set of HIV-serodiscordant homozygous twins and discuss its possible pathogenetic implications.
Case Report: We transplanted abdominal subcutaneous fat from twin 1, the HIV-seronegative donor, to the subcutaneous cheek region of twin 2, the HIV-infected recipient, by using the Coleman technique (3). Twin 2 had been HIV-infected for 18 years and was extensively treated with all 3 major classes of antiretrovirals, notably including stavudine for 50 months. Neither twin was obese (body mass index was 19 kg/m2 for twin 1 and 16 kg/m2 for twin 2). The local institutional review board authorized the procedure.
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Guaraldi G, Squillace N, De Fazio D, Prestileo T, Palella F. Heterologous Fat Transplantation for the Treatment of HIV-Related Facial Lipoatrophy. Ann Intern Med. ;150:61–63. doi: 10.7326/0003-4819-150-1-200901060-00022

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Published: Ann Intern Med. 2009;150(1):61-63.

DOI: 10.7326/0003-4819-150-1-200901060-00022

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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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