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ACP Journal Club |21 April 2009

Review: Brand-name drugs are not more effective than generic versions for treating cardiovascular disease

Braden Manns, MD

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Kesselheim AS, Misono AS, Lee JL, et al. Clinical equivalence of generic and brand-name drugs used in cardiovascular disease: a systematic review and meta-analysis. JAMA. 2008;300:2514-26. 19050195

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Kesselheim and colleagues have conducted a comprehensive review of studies comparing the effectiveness of generic and brand-name drugs. As noted in the editorials discussed in this article, many physicians are uncomfortable with the notion of generic substitution, possibly due to anecdotal experience or a perception that the physician’s direction has been subverted. However, generic drugs are typically more than 30% less expensive, which can be important to cash-strapped health care...
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Manns B. Review: Brand-name drugs are not more effective than generic versions for treating cardiovascular disease. Ann Intern Med. 2009;150:JC4–6. doi: 10.7326/0003-4819-150-8-200904210-02006

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Published: Ann Intern Med. 2009;150(8):JC4-6.

DOI: 10.7326/0003-4819-150-8-200904210-02006

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