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Letters |17 March 2009

Questioning the Accuracy of a Recent Review of Osteoporosis Medications

Catherine MacLean, MD, PhD; Marika Suttorp, MS

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Potential Financial Conflicts of Interest: None disclosed.
  • From RAND Corporation, Santa Monica, CA 90407.
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Potential Financial Conflicts of Interest: None disclosed.
IN RESPONSE:
The concerns of Ms. Kuhl and colleagues about our article and the report from which it was derived (1) can be grouped into 3 categories: questions about how meta-analysis could find a statistically significant association between a drug and an outcome when none of the individual studies reported a statistically significant association, questions about what outcomes and studies should have been included in the review, and errors of fact.
First, the fact that a meta-analytic pooled result shows a statistically significant association when none of the individual studies themselves did so...
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MacLean C, Suttorp M. Questioning the Accuracy of a Recent Review of Osteoporosis Medications. Ann Intern Med. 2009;150:424–425. doi: 10.7326/0003-4819-150-6-200903170-00016

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Published: Ann Intern Med. 2009;150(6):424-425.

DOI: 10.7326/0003-4819-150-6-200903170-00016

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