David Siegel, MD, MPH
In patients with heart failure (HF), are nonsteroidal antiinflammatory drugs (NSAIDs) associated with increased risks for death and hospitalization for HF and myocardial infarction (MI)?
Cohort study with ≤ 10 years of follow-up.
107 092 patients who were ≥ 30 years of age (mean age 75 y, 52% men) and survived their first hospitalization for HF.
Prescribed use of NSAIDs (i.e., rofecoxib, celecoxib, ibuprofen, diclofenac, naproxen, and other NSAIDs [categorized as a single group]). The Danish Registry of Medicinal Product Statistics was linked to the Danish National Patient Registry.
Death (Central Population Registry) and hospitalization for MI or HF (Danish National Patient Registry).
34% of patients with HF received ≥ 1 prescription for an NSAID. 60 974 patients died, 8970 were hospitalized for MI, and 39 894 were hospitalized for HF. After adjustment for age, sex, year of first hospitalization, severity (loop diuretic dosage), concomitant medical treatment, and comorbid conditions, use of NSAIDs was associated with increased risks for death, hospitalization for MI, and hospitalization for HF (Table).
In patients with HF, use of nonsteroidal antiinflammatory drugs was associated with increased risks for death, hospitalization for myocardial infarction, and hospitalization for heart failure.
Associations between use of NSAIDs and risks for death and hospitalizations*
* HF = heart failure; MI = myocardial infarction; NSAIDs = nonsteroidal antiinflammatory drugs.
†Adjusted for age, sex, year of first hospitalization, severity (loop diuretic dosage), concomitant medical treatment, and comorbid conditions.
Siegel D. Use of nonsteroidal antiinflammatory drugs was associated with increased risks for death and hospitalization for MI and HF. Ann Intern Med. 2009;150:JC6–12. doi: 10.7326/0003-4819-150-12-200906160-02012
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Published: Ann Intern Med. 2009;150(12):JC6-12.
Cardiology, Heart Failure, Hospital Medicine.
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