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ACP Journal Club |17 November 2009

Review: Evidence for the effectiveness of vitamin D and calcium for reducing CV outcomes, cancer, and death is limited

Joel A. Simon, MD, MPH

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Chung M, Balk EM, Brendel M, et al. Vitamin D and calcium: a systematic review of health outcomes. Evid Rep No. 183. Rockville, MD: Agency for Healthcare Research and Quality; 2009. [PMID: Not available]

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A 2007 meta-analysis of 18 RCTs showed that vitamin D supplementation, with or without calcium, reduced risk for death (relative risk reduction [RRR] 7%, 95% CI 1 to 13) (1). The review by Chung and colleagues reanalyzed these data, excluding 5 of the 18 studies, adding 2 trials, and stratifying their results by studies of vitamin D supplementation without calcium (4...
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Simon JA. Review: Evidence for the effectiveness of vitamin D and calcium for reducing CV outcomes, cancer, and death is limited. Ann Intern Med. 2009;151:JC5–5. doi: 10.7326/0003-4819-151-10-200911170-02005

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Published: Ann Intern Med. 2009;151(10):JC5-5.

DOI: 10.7326/0003-4819-151-10-200911170-02005

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