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ACP Journal Club |17 November 2009

Review: PPI use in pregnancy was not associated with increased congenital malformations, spontaneous abortion, or preterm delivery

Adil E. Bharucha, MD

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Gill SK, O’Brien L, Einarson TR, Koren G. The safety of proton pump inhibitors (PPIs) in pregnancy: a meta-analysis. Am J Gastroenterol. 2009;104:1541-5. 19491869

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Gastroenterology:

Approximately 50% of pregnant women have reflux. PPIs are widely used to treat reflux outside of, but not during, pregnancy because animal experiments have shown that therapeutic doses of omeprazole (US Food and Drug Administration category C) increase embryonic and fetal mortality and that excessive doses have teratogenic effects (1). Other PPIs (lansoprazole and esomeprazole) have low risk for toxicity (category B) in human studies (2). Therefore, a “step-up” regimen using conservative...
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Bharucha AE. Review: PPI use in pregnancy was not associated with increased congenital malformations, spontaneous abortion, or preterm delivery. Ann Intern Med. 2009;151:JC5–14. doi: 10.7326/0003-4819-151-10-200911170-02014

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Published: Ann Intern Med. 2009;151(10):JC5-14.

DOI: 10.7326/0003-4819-151-10-200911170-02014

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