Skip Navigation
Menu
ACP Journal Club |17 November 2009

Review: PPI use in pregnancy was not associated with increased congenital malformations, spontaneous abortion, or preterm delivery

Adil E. Bharucha, MD

Article, Author, and Disclosure Information
FULL TEXT
Gill SK, O’Brien L, Einarson TR, Koren G. The safety of proton pump inhibitors (PPIs) in pregnancy: a meta-analysis. Am J Gastroenterol. 2009;104:1541-5. 19491869

GIM/FP/GP:

Gastroenterology:

Approximately 50% of pregnant women have reflux. PPIs are widely used to treat reflux outside of, but not during, pregnancy because animal experiments have shown that therapeutic doses of omeprazole (US Food and Drug Administration category C) increase embryonic and fetal mortality and that excessive doses have teratogenic effects (1). Other PPIs (lansoprazole and esomeprazole) have low risk for toxicity (category B) in human studies (2). Therefore, a “step-up” regimen using conservative...
FULL TEXT
PDF
Not Available
Citations
Citation

Bharucha AE. Review: PPI use in pregnancy was not associated with increased congenital malformations, spontaneous abortion, or preterm delivery. Ann Intern Med. 2009;151:JC5–14. doi: https://doi.org/10.7326/0003-4819-151-10-200911170-02014

Download citation file:

© 2020

×
Permissions

Published: Ann Intern Med. 2009;151(10):JC5-14.

DOI: 10.7326/0003-4819-151-10-200911170-02014

0 Citations

Related Articles
β-Blocker Use in Pregnancy and the Risk for Congenital Malformations: An International Cohort Study
Annals of Internal Medicine; 169 (10): 665-673
Risk for Congenital Malformation With H1N1 Influenza Vaccine: A Cohort Study With Sibling Analysis
Annals of Internal Medicine; 165 (12): 848-855
Annals for Educators - 20 December 2016
Annals of Internal Medicine; 165 (12): ED12
Low-Molecular-Weight Heparin for Women With Unexplained Recurrent Pregnancy Loss: A Multicenter Trial With a Minimization Randomization Scheme
Annals of Internal Medicine; 162 (9): 601-609
View MoreView Less

Journal Club
Metoclopramide during pregnancy did not increase risk for major congenital malformations or fetal death
Annals of Internal Medicine; 160 (4): JC13
Fluconazole use during the first trimester of pregnancy was not associated with most major birth defects
Annals of Internal Medicine; 160 (2): JC12
PPI use in the first trimester was not associated with increased risk for birth defects; PPI use 1 to 4 weeks before conception was
Annals of Internal Medicine; 154 (12): JC6-11
Guideline: Recommendations are provided for antiretroviral therapies in pregnant women with HIV
Annals of Internal Medicine; 168 (4): JC14
View MoreView Less

Related Point of Care
Contraception
Annals of Internal Medicine; 170 (3): ITC18-ITC32
Contraception
Annals of Internal Medicine; 157 (7): ITC4-1
View MoreView Less

Related Topics
Esophageal Disorders
Gastroenterology/Hepatology
Gastroesophageal Reflux Disease
Peptic Disease
Prevention/Screening

Esophageal Disorders, Gastroenterology/Hepatology, Gastroesophageal Reflux Disease, Peptic Disease, Prevention/Screening.

PubMed Articles
Outcome of selective intrauterine growth restriction in monochorionic twin pregnancies at 16, 20 or 30 weeks according to the new consensus definition.
Ultrasound Obstet Gynecol 2020.
Economic burden of maternal morbidity - A systematic review of cost-of-illness studies.
PLoS One 2020;15(1):e0227377.
View More

Results provided by: PubMed

CONTINUE WITH LIMITED ACCESS
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×
acp link acp
silverchair link silverchair

Copyright © 2020 American College of Physicians. All Rights Reserved.

Print ISSN: 0003-4819 | Online ISSN: 1539-3704

Privacy Policy

|

Conditions of Use

This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy. | Accept
×

You need a subscription to this content to use this feature.

×
PDF Downloads Require Access to the Full Article.
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×
Access to this Free Content Requires Users to be Registered and Logged In. Please Choose One of the Following Options
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×