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ACP Journal Club |15 December 2009

Human papillomavirus 16/18 AS04-adjuvanted vaccine prevented cervical intraepithelial neoplasia in young women

Kavita Nanda, MD, MHS

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Paavonen J, Naud P, Salmerón J, et al. Efficacy of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by oncogenic HPV types (PATRICIA): final analysis of a double-blind, randomised study in young women. Lancet. 2009;374:301-14. 19586656

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Infectious Disease:

Oncology:

Previous trials showed the effectiveness of HPV vaccines in preventing CIN (1, 2). New findings from the trial by Paavonen and colleagues include data on preventing CIN3+ and cross-protection. In the per-protocol analysis, vaccine efficacy against HPV-16/18 was 80% for CIN3+, whereas it was 34% in the intention-to-treat population. In HPV-naïve women, efficacy against CIN3+ was...
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Nanda K. Human papillomavirus 16/18 AS04-adjuvanted vaccine prevented cervical intraepithelial neoplasia in young women. Ann Intern Med. 2009;151:JC6–6. doi: 10.7326/0003-4819-151-12-200912150-02006

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Published: Ann Intern Med. 2009;151(12):JC6-6.

DOI: 10.7326/0003-4819-151-12-200912150-02006

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