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Letters |1 December 2009

Is Lifelong Anticoagulation Worth the Risk in Patients With Unprovoked DVT?

Samuel Z. Goldhaber, MD

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Potential Conflicts of Interest: None disclosed.
  • From Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115.
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Potential Conflicts of Interest: None disclosed.
IN RESPONSE:
PREVENT studied the optimal management of patients with an initial idiopathic and unprovoked VTE. Although PREVENT was not powered to assess mortality, the data monitoring and safety board terminated the study early because of the marked reduction in recurrent VTE in the low-intensity warfarin group (target international normalized ratio, 1.5 to 2.0) compared with the placebo group. I am not aware of any cancer risk with warfarin, which has been available in the United States since 1954. The long-term risk for recurrent VTE after an initial DVT or pulmonary embolism is high,...
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Goldhaber SZ. Is Lifelong Anticoagulation Worth the Risk in Patients With Unprovoked DVT?. Ann Intern Med. 2009;151:827. doi: https://doi.org/10.7326/0003-4819-151-11-200912010-00028

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Published: Ann Intern Med. 2009;151(11):827.

DOI: 10.7326/0003-4819-151-11-200912010-00028

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