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Letters |2 March 2010

Varenicline and Pheochromocytoma

Janne Hukkanen, MD, PhD; Olavi Ukkola, MD, PhD; Neal L. Benowitz, MD

Article, Author, and Disclosure Information
Author, Article, and Disclosure Information
Potential Conflicts of Interest: None disclosed.
  • From Oulu University Hospital, Oulu, FI-90029, Finland; and University of California, San Francisco, San Francisco, CA 94143.
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Potential Conflicts of Interest: None disclosed.
Background: Varenicline is a widely used smoking-cessation therapy. It acts as an α4β2 nicotinic acetylcholine receptor (nAChR) partial agonist to diminish the symptoms of nicotine withdrawal.
Objective: To report a case of varenicline-triggered pheochromocytoma crisis.
Case Report: A 55-year-old woman who smoked about 15 cigarettes a day for decades had hypertension, hypothyroidism, and an 8-year history of palpitations. She was prescribed varenicline. Her medications included stable doses of telmisartan and l-thyroxine.
The patient took one 0.5-mg varenicline tablet without ill effects, but after taking the second varenicline tablet the next day,...
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Hukkanen J, Ukkola O, Benowitz NL. Varenicline and Pheochromocytoma. Ann Intern Med. 2010;152:335–336. doi: 10.7326/0003-4819-152-5-201003020-00021

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Published: Ann Intern Med. 2010;152(5):335-336.

DOI: 10.7326/0003-4819-152-5-201003020-00021

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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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