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Letters |6 April 2010

Another Side to Statin-Related Side Effects

Hans Knoblauch, MD; Verena Schoewel, MD; Adrian Rosada, MD; Simone Spuler, MD; Wolfram Kress, PhD

Article, Author, and Disclosure Information
Author, Article, and Disclosure Information
Note: Drs. Knoblauch and Schoewel contributed equally.
Grant Support: By the German Research Foundation (KFO 192).
Potential Conflicts of Interest: None disclosed.
  • From Charité University Medicine, 13125 Berlin, Germany, and Julius-Maximilian University, 97070 Würzburg, Germany.
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Note: Drs. Knoblauch and Schoewel contributed equally.
Grant Support: By the German Research Foundation (KFO 192).
Potential Conflicts of Interest: None disclosed.
Background: Millions of persons take statins to reduce cardiovascular risk, and about 5% of those who take statins develop skeletal muscle symptoms and increased creatine kinase levels (1). A variant in the gene SLCO1B1 increases susceptibility for this side effect by 5-fold (2). We reasoned that variants in other genes could occur in patients who were referred to us because of increased levels of creatine kinase and muscle pain or cramps.
Objective: To describe 3 patients in whom statin treatment unmasked an underlying muscle disorder.
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Knoblauch H, Schoewel V, Rosada A, Spuler S, Kress W. Another Side to Statin-Related Side Effects. Ann Intern Med. 2010;152:478–479. doi: 10.7326/0003-4819-152-7-201004060-00025

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Published: Ann Intern Med. 2010;152(7):478-479.

DOI: 10.7326/0003-4819-152-7-201004060-00025

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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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