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In the Clinic |6 July 2010

Rheumatoid Arthritis

Tom W.J. Huizinga, MD, PhD; Theodore Pincus, MD

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Editor's Note: This issue of In the Clinic has been updated.
Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disease affecting approximately 0.5% of the population. Rheumatoid arthritis is more common in women and may occur at any age, with peak incidence at ages 50 to 60 years. The most prominent feature is symmetrical joint swelling of the feet, hands, and knees, although any joint (and some internal organs) may be affected. Rheumatoid arthritis is a clinical syndrome encompassing several disease subsets, each involving inflammatory cascades that generally lead to joint and organ damage if left untreated. Although laboratory test results are abnormal in most patients, many patients have normal values, and there is no pathognomonic laboratory finding for RA. The diagnosis is based on a pattern of symptoms and physical examination findings, with and often without any radiographic or serologic abnormalities.
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Huizinga TW, Pincus T. Rheumatoid Arthritis. Ann Intern Med. ;153:ITC1–1. doi: 10.7326/0003-4819-153-1-201007060-01001

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Published: Ann Intern Med. 2010;153(1):ITC1-1.

DOI: 10.7326/0003-4819-153-1-201007060-01001

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2010 American College of Physicians
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