Vincent Mallet, MD, PhD; Elisabeth Nicand, MD; Philippe Sultanik, MD; Catherine Chakvetadze, MD; Sophie Tessé, PhD; Eric Thervet, MD, PhD; Luc Mouthon, MD, PhD; Philippe Sogni, MD, PhD; Stanislas Pol, MD, PhD
There is currently no accepted treatment of chronic hepatitis E virus (HEV) infection.
To report 2 patients in whom ribavirin therapy seemed to alter the natural history of chronic HEV infection.
Hepatology unit of a tertiary care center in France.
A kidney and pancreas transplant recipient and a patient with idiopathic CD4+ T lymphocytopenia, both with biopsy-proven chronic HEV infection.
Patients received oral ribavirin, 12 mg/kg of body weight daily for 12 weeks.
Liver function tests, detection of HEV RNA (viremia and stool shedding) by reverse transcriptase polymerase chain reaction, and anti-HEV IgM and IgG antibodies.
Both patients had normalized liver function test results after 2 weeks of treatment and cleared HEV after 4 weeks of treatment. Hepatitis E virus RNA remained undetectable in the serum and stools throughout follow-up (3 months and 2 months for the first and second patient, respectively). Side effects were considered mild.
Given the relatively short follow-up, the achievement of HEV eradication could not be claimed.
Ribavirin is a potentially effective treatment of HEV infection and should be evaluated in patients with chronic HEV infection.
Mallet V, Nicand E, Sultanik P, et al. Brief Communication: Case Reports of Ribavirin Treatment for Chronic Hepatitis E. Ann Intern Med. 2010;153:85–89. doi: https://doi.org/10.7326/0003-4819-153-2-201007200-00257
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Published: Ann Intern Med. 2010;153(2):85-89.
Gastroenterology/Hepatology, Infectious Disease, Liver Disease.
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