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Letters |1 February 2011

Preventing Alzheimer Disease and Cognitive Decline

Frederick Naftolin, MD, PhD; S. Mitchell Harman, MD, PhD

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Potential Conflicts of Interest: None disclosed.
  • From New York University School of Medicine, New York, NY 10016, and Kronos Longevity Research Institute, Phoenix, AZ 85016.
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Potential Conflicts of Interest: None disclosed.
TO THE EDITOR:
The National Institutes of Health (NIH) State-of-the-Science Conference Panel statement (1) suggesting that estrogen and progesterone may contribute to causation of Alzheimer disease has raised concern and elicited alarmed calls from patients regarding their future. We believe that the panel's conclusion is erroneous because it is based solely on the outcome of the Women's Health Initiative (WHI) trial's substudy WHIMS (Women's Health Initiative Memory Study), which had the same risk value as that shown in the NIH statement (2).
WHIMS had an inappropriate experimental construction using age-driven postrandomization apportionment of...
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Naftolin F, Harman SM. Preventing Alzheimer Disease and Cognitive Decline. Ann Intern Med. 2011;154:211–212. doi: https://doi.org/10.7326/0003-4819-154-3-201102010-00015

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Published: Ann Intern Med. 2011;154(3):211-212.

DOI: 10.7326/0003-4819-154-3-201102010-00015

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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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