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Letters |1 February 2011

Preventing Alzheimer Disease and Cognitive Decline

Martha L. Daviglus, MD, PhD, MPH; Carl C. Bell, MD; Wade Berrettini, MD, PhD; Phyllis E. Bowen, PhD, RD; E. Sander Connolly Jr., MD; Nancy Jean Cox, PhD; Jacqueline M. Dunbar-Jacob, PhD, RN; Evelyn C. Granieri, MD, MPH, MSEd; Gail Hunt, BA; Kathleen McGarry, PhD; Dinesh Patel, MD; Arnold L. Potosky, PhD; Elaine Sanders-Bush, PhD; Donald Silberberg, MD; Maurizio Trevisan, MD, MS

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Author, Article, and Disclosure Information
Potential Conflicts of Interest: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M10-1019.
  • From Feinberg School of Medicine, Northwestern University, Chicago, IL 60611; University of Illinois at Chicago, Chicago, IL 60608-1264; Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia, PA 19104; University of Illinois at Chicago, College of Applied Health Sciences, Chicago, IL 60612; Columbia University Medical Center, New York, NY 10032; University of Chicago, Chicago, IL 60637; School of Nursing, University of Pittsburgh, Pittsburgh, PA 15261; College of Physicians and Surgeons, Columbia University, New York, NY 10034; National Alliance for Caregiving, Bethesda, MD 20814; University of California, Los Angeles, Los Angeles, CA 90095; Charles E. Smith Life Community Hebrew Home of Greater Washington, Rockville, MD 20852; Cancer Control Program, Lombardi Comprehensive Cancer Center, Washington, DC 20007; Vanderbilt University Medical Center, Nashville, TN 37232; Hospital of the University of Pennsylvania, Philadelphia, PA 19104; and Health Sciences System of the Nevada System of Higher Education, Las Vegas, NV 89103.
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Potential Conflicts of Interest: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M10-1019.
IN RESPONSE:
We agree with Dr. Qiu and colleagues' comments that the etiology of Alzheimer disease is probably determined by multiple factors over the life span. However, after reviewing the existing scientific evidence, including observational studies, clinical trials, and data presented by experts in this condition, we concluded that the data simply do not demonstrate a consistent, strong association between any modifiable risk factor and Alzheimer disease. Efforts to examine these associations to date have been hampered by numerous problems, including limited follow-up, methodological differences across studies in measurement...
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Daviglus ML, Bell CC, Berrettini W, et al. Preventing Alzheimer Disease and Cognitive Decline. Ann Intern Med. 2011;154:212–213. doi: https://doi.org/10.7326/0003-4819-154-3-201102010-00016

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Published: Ann Intern Med. 2011;154(3):212-213.

DOI: 10.7326/0003-4819-154-3-201102010-00016

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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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