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Letters |1 February 2011

Animal, Vegetable, or … Clinical Trial?

Teresa T. Fung, ScD; Walter C. Willett, MD, DrPH; Frank B. Hu, MD, PhD

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Author, Article, and Disclosure Information
Potential Conflicts of Interest: None disclosed.
  • From Simmons College, Boston, MA 02115, and Harvard School of Public Health, Boston, MA 02115.
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Potential Conflicts of Interest: None disclosed.
TO THE EDITOR:
In their editorial that accompanied our article on low-carbohydrate diets and mortality (1), Yancy and colleagues (2) raised methodological issues to cast doubts on the value of observational studies as well as to state criticisms specific to our paper. These methodological issues include unmeasured confounding, measurement errors, and discrepant results from observational studies and randomized clinical trials.
In our article, we addressed the potential influence of unmeasured confounders by using a sensitivity analysis that tests the robustness of the results (3). As we stated, the unmeasured confounder would have to have a relative risk of 2.0 and a high prevalence to render our results nonsignificant. Because we adjusted for strong predictors of major causes of mortality in our analyses, it is unlikely that we missed unmeasured confounders that would have such a strong influence on our results.
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Fung TT, Willett WC, Hu FB. Animal, Vegetable, or … Clinical Trial?. Ann Intern Med. ;154:215. doi: 10.7326/0003-4819-154-3-201102010-00020

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Published: Ann Intern Med. 2011;154(3):215.

DOI: 10.7326/0003-4819-154-3-201102010-00020

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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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