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Letters |5 July 2011

Autologous Mesenchymal Stem Cells Foster Revascularization of Ischemic Limbs in Systemic Sclerosis

Jeong H. Yun, MD, MPH

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Potential Conflicts of Interest: None disclosed.
  • From Albert Einstein Medical Center, Philadelphia, PA 19141.
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Potential Conflicts of Interest: None disclosed.
TO THE EDITOR:
The case report by Guiducci and colleagues (1) presents the therapeutic potential of autologous mesenchymal stem cells (MSCs) for patients with systemic sclerosis. The authors suggest that factors expressed from MSCs and the ability of MSCs to differentiate into endothelial and vascular smooth muscle cells account for the observed revascularization. The potential immunosuppressive effect of MSCs also may have contributed to the positive outcome.
It is well-documented that MSCs suppress inflammation through soluble factors and direct physical contact, affecting the innate as well as the adaptive immune system (2). Researchers...
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Yun JH. Autologous Mesenchymal Stem Cells Foster Revascularization of Ischemic Limbs in Systemic Sclerosis. Ann Intern Med. 2011;155:65. doi: 10.7326/0003-4819-155-1-201107050-00013

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Published: Ann Intern Med. 2011;155(1):65.

DOI: 10.7326/0003-4819-155-1-201107050-00013

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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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