Skip Navigation
Menu
Letters |5 July 2011

Autologous Mesenchymal Stem Cells Foster Revascularization of Ischemic Limbs in Systemic Sclerosis

Jeong H. Yun, MD, MPH

Article, Author, and Disclosure Information
Author, Article, and Disclosure Information
Potential Conflicts of Interest: None disclosed.
  • From Albert Einstein Medical Center, Philadelphia, PA 19141.
×
FULL TEXT
Potential Conflicts of Interest: None disclosed.
TO THE EDITOR:
The case report by Guiducci and colleagues (1) presents the therapeutic potential of autologous mesenchymal stem cells (MSCs) for patients with systemic sclerosis. The authors suggest that factors expressed from MSCs and the ability of MSCs to differentiate into endothelial and vascular smooth muscle cells account for the observed revascularization. The potential immunosuppressive effect of MSCs also may have contributed to the positive outcome.
It is well-documented that MSCs suppress inflammation through soluble factors and direct physical contact, affecting the innate as well as the adaptive immune system (2). Researchers...
FULL TEXT
PDF
Not Available
Citations
Citation

Yun JH. Autologous Mesenchymal Stem Cells Foster Revascularization of Ischemic Limbs in Systemic Sclerosis. Ann Intern Med. 2011;155:65. doi: https://doi.org/10.7326/0003-4819-155-1-201107050-00013

Download citation file:

© 2020

×
Permissions

Published: Ann Intern Med. 2011;155(1):65.

DOI: 10.7326/0003-4819-155-1-201107050-00013

2 Citations
CONTINUE WITH LIMITED ACCESS
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×
acp link acp
silverchair link silverchair

Copyright © 2020 American College of Physicians. All Rights Reserved.

Print ISSN: 0003-4819 | Online ISSN: 1539-3704

Privacy Policy

|

Conditions of Use

This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy. | Accept
×

You need a subscription to this content to use this feature.

×
PDF Downloads Require Access to the Full Article.
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×
Access to this Free Content Requires Users to be Registered and Logged In. Please Choose One of the Following Options
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×