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ACP Journal Club |16 August 2011

Calcium plus vitamin D was associated with increased cardiovascular risk in women not taking personal calcium supplements

Carolyn J. Crandall, MD, MS; Jane A. Cauley, DrPH

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Bolland MJ, Grey A, Avenell A, Gamble GD, Reid IR. Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women’s Health Initiative limited access dataset and meta-analysis. BMJ. 2011;342:d2040. 21505219

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The WHI CaD trial is the largest randomized controlled trial (RCT) of calcium plus vitamin D supplementation to date, and CV events were centrally adjudicated. Calcium plus vitamin D was not associated with CV events in the full trial, or in analyses stratified by calcium or vitamin D intake (1).
The results of the reanalysis of...
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Crandall CJ, Cauley JA. Calcium plus vitamin D was associated with increased cardiovascular risk in women not taking personal calcium supplements. Ann Intern Med. 2011;155:JC2–3. doi: 10.7326/0003-4819-155-4-201108160-02003

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Published: Ann Intern Med. 2011;155(4):JC2-3.

DOI: 10.7326/0003-4819-155-4-201108160-02003

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