Metformin was also favored over sulfonylureas for cardiovascular mortality (low-quality evidence), as evidenced by 4 cohort studies (92, 94, 96, 101), although 1 prospective cohort study (94) showed slightly higher cardiovascular mortality rates for metformin than for sulfonylurea monotherapy. Also, ADOPT (A Diabetes Outcome Progression Trial) (89) reported only 1 fatal CHF event in patients treated with either metformin or glyburide (nonstatistically significant difference), but patients treated with glyburide generally experienced fewer CHF as well as cardiovascular events.
. Correction: Oral Pharmacologic Treatment of Type 2 Diabetes Mellitus. Ann Intern Med. 2012;157:152. doi: https://doi.org/10.7326/0003-4819-157-2-201207170-00026
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Published: Ann Intern Med. 2012;157(2):152.
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