Lori K. Handy, MD, MSCE; Paul A. Offit, MD
Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M17-1044.
Requests for Single Reprints: Lori K. Handy, MD, MSCE, Children's Hospital of Philadelphia, Abramson Research Building, Room 1202, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104; e-mail, email@example.com.
Current Author Addresses: Drs. Handy and Offit: Children's Hospital of Philadelphia, Abramson Research Building, Room 1202, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104.
June 5, 2019
Sweeping safety claims are based on a flimsy piece of evidence
Drs. Handy and Offit claim: "The risks are minimal for the individual who receives the vaccine and are greatly outweighed by the benefit to the traveler, as well as to society, on his or her return." They cite Sukumaran et al. to support the claim. Sukumaran et al. reviewed VAERS for reports of adverse events in adults following MMR administration over a 10 year period. Passive surveillance systems such as VAERS are widely known to underreport. A major safety concern with the MMR vaccine is type 1 diabetes (T1D) as I explain in my comment here:https://annals.org/aim/fullarticle/2626466/missed-opportunities-measles-mumps-rubella-vaccination-among-departing-u-sCorrelation of type 1 diabetes trends in European countries to the number of bovine insulin and GAD65 contaminated chick embryo cell culture containing vaccines in the schedule, as predicted by the autoimmunity mechanism involving immunization with homologous xenogeneic antigens and EPIT as a potential treatmenthttps://doi.org/10.5281/zenodo.1870364T1D can take years or even decades to manifest following MMR vaccine administration. The chance of such events being reported to VAERS are practically zero.Therefore Drs. Handy and Offit should refrain from making such sweeping safety claims based on such a flimsy piece of evidence.
Handy LK, Offit PA. Why Aren't International Travelers Vaccinated for Measles?. Ann Intern Med. 2017;167:127–128. [Epub ahead of print 16 May 2017]. doi: https://doi.org/10.7326/M17-1044
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Published: Ann Intern Med. 2017;167(2):127-128.
Published at www.annals.org on 16 May 2017
Infectious Disease, Prevention/Screening, Vaccines/Immunization.
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