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Summaries for Patients |6 March 2018

Effect of Physical Activity on Frailty Free

Article, Author, and Disclosure Information
Author, Article, and Disclosure Information
This article was published at Annals.org on 9 January 2018.

  • The full report is titled “Effect of Physical Activity on Frailty. Secondary Analysis of a Randomized Controlled Trial.” The authors are A. Trombetti, M. Hars, F.C. Hsu, K.F. Reid, T.S. Church, T.M. Gill, A.C. King, C.K. Liu, T.M. Manini, M.M. McDermott, A.B. Newman, W.J. Rejeski, J.M. Guralnik, M. Pahor, and R.A. Fielding, for the LIFE Study Investigators.


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    • Why did the researchers do this particular study?
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What is the problem and what is known about it so far?

Frailty is often associated with aging. Older adults who are frail may have muscle weakness, unintended weight loss, and fatigue, and they may need help with activities of daily living (for example, taking a bath or putting on clothing). Some studies suggest that teaching older adults to be more physically active helps improve physical functioning and may help decrease their risk for becoming frail.

Why did the researchers do this particular study?

The investigators wanted to compare the effects of a long-term exercise program with those of a health education program on the study participants' risk for becoming frail. They also wanted to see whether the benefits of the exercise program on physical functioning differed for participants who were frail at baseline compared with those who were not.

Who was studied?

1,635 older adults, aged 70 to 89 years, who were not physically active and had functional limitations. To participate in the study, they had to be able to walk a quarter mile (400 meters) without the help of another person or using a walker.

How was the study done?

The researchers analyzed data collected for a trial that was completed in 2013. In the trial, the participants were randomly assigned to receive either a structured exercise program or a health education program for about 3 years. A standard definition was used to classify whether the participants were frail. This definition consisted of measurements of the participants' ability to get up from a chair without using their arms, weight loss, and energy level. The researchers saw the participants every 6 months to measure their ability to walk independently. Major mobility disability (MMD) was defined as not being able to walk a quarter mile within 15 minutes without assistance.

What did the researchers find?

During the follow-up, the risk for becoming frail did not differ between the group that received the exercise intervention and the group that received health education. Compared with health education, the exercise intervention was associated with improvement in the participants' ability to get up from a chair without using their arms. The positive effects of the exercise intervention on the proportion of participants who developed new episodes of MMD or long-term MMD were not affected by whether they were frail at baseline.

What were the limitations of the study?

The original trial was not designed to answer the question these researchers were asking.

What are the implications of the study?

A structured exercise program was not associated with a decreased risk for frailty among older adults. However, the beneficial effect of the exercise program on reducing MMD was not affected by whether the participants were frail at baseline.

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Effect of Physical Activity on Frailty. Ann Intern Med. 2018;168:I–22. [Epub ahead of print 9 January 2018]. doi: https://doi.org/10.7326/P17-9052

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Published: Ann Intern Med. 2018;168(5):I-22.

DOI: 10.7326/P17-9052

Published at www.annals.org on 9 January 2018

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2018 American College of Physicians
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