The full report is titled “Hydroxychloroquine Effectiveness in Reducing Symptoms of Hand Osteoarthritis. A Randomized Trial.” The authors are S.R. Kingsbury, P. Tharmanathan, A. Keding, S.J. Ronaldson, A. Grainger, R.J. Wakefield, C. Arundel, F. Birrell, M. Doherty, T. Vincent, F.E. Watt, K. Dziedzic, T.W. O'Neill, N.K. Arden, D.L. Scott, J. Dickson, T. Garrood, M. Green, A. Menon, T. Sheeran, D. Torgerson, and P.G. Conaghan.
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Eugene Fung, MD, FRCPC,FACR
University of Texas Southwestern Medical Center
March 26, 2018
If any use, use it in shorter term for inflammatory osteoarthritis
While the dose of Hydroxychloroquine of 200-400mg might not be adequate for Rheumatoid, we do not know what is the proper dose and this study has no information either. For any possible usage in OA is most likely chronic and then the safety of retinopathy might out-weight its benefit. For those of us who had witnessed some response in these inflammatory OA patients we might have to use it for shorter term, and use the safe dose which can be 5mg/Kg actual body weight per AAO 2016 recommendation. Beware of that formula does not address obesity which is not uncommon in OA patents. If not capped at 400mg then the usage of the old formula 6.5mg/Kg ideal body weight will be safer.
Hydroxychloroquine to Reduce Symptoms of Hand Osteoarthritis. Ann Intern Med. [Epub ahead of print 20 February 2018]168:I–30. doi: 10.7326/P17-9055
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Published: Ann Intern Med. 2018;168(6):I-30.
Published at www.annals.org on 20 February 2018
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