Pathophysiology of abetalipoproteinemia.
The combination of decreased plasma levels of chylomicrons and VLDL can be produced by defects in the gene for either MTTP (*) or apolipoprotein B (APOB) (†). Defects in MTTP lead to abetalipoproteinemia, and defects in APOB lead to hypobetalipoproteinemia. Defects in the gene for secretion associated Ras related guanosine triphosphatase 1B (SAR1B) (indicated by a double dagger) impair production of chylomicrons but not VLDL and lead to chylomicron retention disease. apo = apolipoprotein; MTTP = microsomal triglyceride transfer protein; TG = triglycerides; VLDL = very-low-density lipoprotein.
Temporal conjunctival surface of the left eye showing an extreme sicca syndrome with vacuolization and keratinization (Bitot spots).
ICU admissions and beds over time, by state.
Relationship between age- and sex-adjusted ICU admission rates among Medicare fee-for-service beneficiaries aged ≥65 y in each state and total ICU beds in 2006 and 2015. Lines represent a locally weighted regression curve with shaded 95% CIs. The Spearman ρ is reported with 95% bootstrapped CIs (based on 10 000 replicates). The correlation between ICU admissions and number of beds increased between 2006 (Spearman ρ, 0.28 [95% CI, 0.01–0.52]) and 2015 (Spearman ρ, 0.58 [CI, 0.30–0.77]). ICU = intensive care unit.
Percentage of change in ICU beds and admissions.
Percentage of change in ICU admissions per 100 000 persons aged ≥65 y vs. percentage of change in total ICU beds per 100 000 persons in each state. Lines represent a locally weighted regression curve with shaded 95% CIs. The Spearman ρ is reported with 95% bootstrapped CIs (based on 10 000 replicates). The percentage changes in ICU beds and admissions between 2006 and 2015 were not correlated (Spearman ρ, 0.03 [95% CI, −0.24 to 0.30]). ICU = intensive care unit.
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Correction: Error in Letters in 5 February 2019. Ann Intern Med. 2019;170:668–669. doi: 10.7326/L19-0227
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Published: Ann Intern Med. 2019;170(9):668-669.
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